方向1.自身免疫性疾病的发病机制以及植物中有效成分对癌症、免疫性疾病的药物靶点筛选研究。
发表文章
1. Zhang Yu, Luo Jia, Liu Zhe, Liu Xudong, Ma Ying, Zhang Bohang, Chen Yuxuan, Li Xiaofeng, Feng Zhiguo, Yang Ningning, Feng Dayun, Wang Lei, Song Xinqiang*. Identification of hub genes in colorectal cancer based on weighted gene co-expression network analysis.[J]. Bioscience reports,2021:
2. Xinqiang S*, Erqin D, Yu Z, Hongtao D, Lei W, Ningning Y. Potential mechanisms of action of celastrol against rheumatoid arthritis: Transcriptomic and proteomic analysis. PLoS One. 2020 Jul 29;15(7):e0233814.
3. Song X*, Zhang Y, Dai E, Wang L, Du H. Prediction of triptolide targets in rheumatoid arthritis using network pharmacology and molecular docking. Int Immunopharmacol. 2020 Mar;80:106179.
4. Xinqiang S*, Yu Z, Ningning Y, Erqin D, Lei W, Hongtao D. Molecular mechanism of celastrol in the treatment of systemic lupus erythematosus based on network pharmacology and molecular docking technology. Life Sci. 2020 Jan 1;240:117063.
5. Song X*, Zhang Y, Dai E. Therapeutic targets of thunder god vine (Tripterygium wilfordii hook) in rheumatoid arthritis (Review). Mol Med Rep. 2020 Jun;21(6):2303-2310.
6. Song X*, Zhang Y, Dai E, Du H, Wang L. Mechanism of action of celastrol against rheumatoid arthritis: A network pharmacology analysis. Int Immunopharmacol. 2019 Sep;74:105725.
7. Xinqiang Song*, Mu Zhang, Lei Chen, Qingsong Lin. Bioinformatic Prediction of Possible Targets and Mechanisms of Action of the Green Tea Compound Epigallocatechin-3-Gallate Against Breast Cancer. Front Mol Biosci 2017;4:43.
8. Xinqiang Song*, Qingsong Lin. Genomics, transcriptomics and proteomics to elucidate the pathogenesis of rheumatoid arthritis. Rheumatol Int, 2017, 37(8):1257-1265.
9. Xinqiang S* , Mu Z , Lei C , Mun L.Y. Bioinformatics Analysis on Molecular Mechanism of Green Tea Compound Epigallocatechin‐3‐Gallate Against Ovarian Cancer. Clinical and Translational Science,10,4(2017-05-23), 2017.
方向2.抗病毒天然免疫
发表文章
1.Wei Guo#, Jin Wei#, Xuan Zhong, Ru Zang, Huan Lian, Ming-Ming Hu, Hong-Bing Shu*, Qing Yang*.(2019).SNX8 modulates the innate immune response to RNA viruses by regulating the aggregation of VISA. Cell Mol Immunol.
2.Jin Wei, Wei Guo, Huan Lian, Qing Yang, Heng Lin, Shu Li*, Hong-Bing Shu*.(2017).SNX8 Mediates IFNγ-triggered Noncanonical Signaling Pathway and Host Defense Against Listeria monocytogenes. Proc Natl Acad Sci U S A.
3. Jin Wei#, Huan Lian#, Wei Guo, Yun-Da Chen, Xia-Nan Zhang, Ru Zang, Li Zhong, Qing Yang, Ming-Ming Hu, Wei-Wei Luo, Hong-Bing Shu*, Shu Li*.(2018).SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA. PLoS Pathog.
4. Ze-Min Song, Heng Lin, Xue-Mei Yi, Wei Guo, Ming-Ming Hu, Hong-Bing Shu*.(2020).KAT5 acetylates cGAS to promote innate immune response to DNA virus. Proc Natl Acad Sci U S A.
方向3.天然产物活性成分挖掘，植物中的活性化合物结构、构效关系及抗癌机制研究
发表文章
1. Meng Sun, Shiqiao Peng, Changli Zhao, Juexin Huang, Jingyi Xia, Dan Ye, Xiaoqiu Dou, Wanying Hou, Chuanliang Feng*, Herb-functionalized chronic wound dressings for enhancing biological functions: multiple flavonoids coordination driven strategy, Advanced Functional Materials, 2022, DOI:10.1002/adfm.202204291.
2. Meng Sun, Fangfang Yang, Wanying Hou, Shuangfeng Jiang, Runqi Yang, Wei Zhang, Mingjie Chen, Yuhang Yan, Yuxin Tian and Hongyu Yuan*, Dynamic variation of amino acid contents and identification of sterols in xinyang mao jian green tea. Molecules, 2022, 27, 3562-3575.
3. Meng Sun, Shiqiao Peng, Lei Nie, Yunqing Zou, Li Yang, Laiben Gao, Xiaoqiu Dou, Changli Zhao, Chuanliang Feng*, Three-dimensional chiral supramolecular microenvironment strategy for enhanced biocatalysis, ACS Nano, 2021, 15(9): 14972-14984.
4. Meng Sun, Yaxiong Chen, Burong Hu*, The inhibition of DNA damage response contributes to cancer radiotherapy, International Journal of Radiology, 2018, 5(1): 149-156.
5. Meng Sun, Dong Pan, Ya Li, Yaxiong Chen, Kun Gao* and Burong Hu*, CGN enhances the radiosensitivity of human lung cancer cells through Nrf2/ROS pathway, Oncotarget. 2017, 8: 32807-32820.
